To add to Kaitlin’s comment, after you go up and downstream (look up kinetic chains or anatomy trains, basically groups of muscles that work together to perform movements), there could be muscle imbalances or technique problems in your friend’s movements.  Say your friend is a runner.  She could have problems in her running technique which cause the big knot to form in her calf.  Your mob might remove it or calm it down, but she doesn’t address her running technique, it will undoubtedly come back every time she runs…  So I would also explore someone who can take a look at her form and technique in whatever sport she is in.